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doi: 10.1016/j.jff.2023.105596 32 HamidMAbdulrahimYLiuDQianGKhanAHuangK

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FIGURE 4 4.2 Enhanced CDT and ferroptotic therapy In the past few decades, CDT has become an emerging invasive TME-responsive cancer treatment based on Fenton or a Fenton-like reaction, which uses transition metal (including Fe, Mn, and Cu) to convert endogenous abundant H 2 O 2 into highly toxic OH, contributing to irreversible cellular damage