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Another change in 2026 is that the non-diagnostic use of carbon monoxide (CO) was added as a new section , M 1.4, because it can increase erythropoiesis (red blood cell production) under certain conditions and there are potentially fatal effects when inhaled in high or unregulated doses

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Peripheral whole blood was collected in the perioperative setting via a venous catheter immediately before surgery using K 2 -EDTA-coated tubes (BD Biosciences, 367899)

The choice of DMT is impacted by the potential affects of aging on the pharmacokinetics and pharmacodynamics of each drug, the potential for drug-drug interactions with other medications the patient may be taking, and any age-dependent effects on the risk-benefit profile (eg, the risk of natalizumab-related PML increases with age)