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Se han desarrollado numerosos trabajos cientficos para conocer los beneficios del aporte de un aporte extra de l-carnitina a los animales

Interestingly, NOX1-null mice are protected from diabetic endothelial dysfunction, and mice lacking components of NOX2 are protected against hypertension and show reduced atherosclerotic lesion formation when crossed with the apoE-/- background (Judkins et al., Figure 1 ROS derived from mitochondria induce the infiltration and activation of inflammatory cells and increase the apoptosis of endothelial and vascular smooth muscle cells (Hulsmans et al., 2010)

Atrial ischemia promotes atrial fibrillation in dogs

Thus, the liver is an ideal target for therapeutic intervention with isoform-specific TH agonists (see the Thyromimetics section)