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This paper shows that owing to the proximity of SMAD4 and ME2 in the genome, SMAD4-mutated pancreatic ductal adenocarcinoma cells also show loss of ME2, and are therefore more dependent on ME3 to generate NADPH

Mancarella D, Plass C

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Later, a phase III trial was conducted in Japan and demonstrated that PFD preserves VC, the primary outcome, and improves progression-free survival time, the second outcome in mild IPF patients (Taniguchi et al., 2010)