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However, this ERK5 destabilization is quantitatively and kinetically much less efficient than the targeted, proximity-induced degradation achieved by the bifunctional ERK5-CHAMP (HLE, RNK06138) with differences in DC 50 and Dmax potencies (Fig

Zhao X, Li Y, Du K et al (2019) Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport

Meanwhile, the metabolomic analysis revealed that MOX-Cu mainly affected amino acid-associated metabolic pathways, including glutathione metabolism, arginine biosynthesis, and purine metabolism, which were closely associated with redox regulation and energy homeostasis (Figs

Because of the presence of APAP in numerous prescription and over-the-counter medications, intentional and unintentional overdosing occurs regularly