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Cysteine is therefore dependent on methionine (an essential amino acid), as it is produced whenever there is sufficient methionine, and a methionine deficiency would in turn cause lower endogenous synthesis of cysteine

The supplemental approval is based on data from the Phase III PhALLCON trial, in which treatment with Iclusig led to superior MRD-negative complete remission rates and had comparable safety to Novartis Gleevec in adults with newly diagnosed Ph+ ALL

It's unclear exactly why they died, but that delayed the field of gene therapy by at least a decade

Current evidence does not justify answering yes for everyone