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and 360% in buccal cells compared to baseline in blood, erythrocytes, plasma

The enzyme NNMT normally changes nicotinamide, a form of vitamin B3, by using methyl groups, which lowers nicotinamide adenine dinucleotide (NAD+) levels

This dependence may allow fine-tuned turnover of numerous substrates involved in cell-cycle control, nuclear factor-B (NF-B) activation, DNA damage response, autophagy and mitophagy 59,60,61,62,63