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2021 Feb;45(1):67-72

This spectrum of defects is quite consistent with a mutant that has a reduced capacity to deal with ROS due to an absence of de novo synthesis of GSH

[72] Targeting the terminal step in acid production, as well as the irreversible nature of the inhibition, results in a class of medications that are significantly more effective than H 2 antagonists and reduce gastric acid secretion by up to 99%