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Long term infection also induced Mbp gene, which maintained myelination and prevented further neuroinflammation 94

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

Non-etheless, new compounds or existing drugs await testing as potential therapeutic strategies for PD via improving ETC functions (Singh et al., 2021)