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Those that have the MTHFR mutation are only able to detox at a rate of 50%, versus someone without the mutation

10.1038/nrm3802 136

QuagliarielloVBerrettaMBiscegliaIGiacobbeIIovineMBarbatoMet alIn the era of cardiovascularkidneymetabolic syndrome in cardio-oncology: from pathogenesis to prevention and therapy