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While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

The additional 2-2.5 kg of loss comes predominantly from fat tissue, reflecting the lipolytic and anti-lipogenic mechanism

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The peptide appears to allosterically modulate GABA-A receptors in a manner pharmacologically similar to benzodiazepines, enhancing inhibitory neurotransmission to reduce anxiety, but without directly binding the benzodiazepine site