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Acquired SA can also be caused by copper deficiency due to malabsorption states (including gastrointestinal resections) or toxic causes such as excess zinc intake (e.g., zinc supplements, coins in some cases of pica [27]) and lead poisoning, also called saturnism [28]

Importantly, redox imbalance acts as the molecular bridge through which IR and HA reinforce each other while maintaining a chronic inflammatory state ( 2.4 Redox-endocrine vicious cycle in PCOS The pathophysiology of PCOS is underlined by a self-reinforcing redox-endocrine loop that integrates OS, hormonal dysregulation, and metabolic dysfunction into a persistent pathological circuit

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