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The study showed that amantadine, modafinil, and methylphenidate were not superior to placebo in improving fatigue and were associated with a higher risk of adverse events (39% to 40%) compared with placebo (31%)

Gut 67, 108119

If a patient becomes pregnant while receiving NAD+, the treatment would be discontinued unless there were extraordinary circumstances and a careful risk-benefit assessment by the healthcare provider

Elevated iron levels are also linked to oxidative stress and ferroptosis, a programmed cell death dependent on intracellular ferrous iron and impaired antioxidant defense systems (Ward et al., 2022)