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To meet the diagnostic criteria for pEDS, a person must meet: Major criterion 1 AND two other major criteria AND one minor criterion OR Major criterion 2 AND two other major criteria AND one minor criterion Major Criteria Severe and intractable periodontitis of early onset (childhood or adolescence) Lack of attached gingiva Pretibial plaques Family history of a first-degree relative who meets the clinical diagnostic criteria for pEDS Minor Criteria Easy bruising Joint hypermobility, mostly distal joints Skin hyperextensibility and fragility, abnormal scarring (wide or atrophic) Increased rate of infections Hernias Marfanoid facial features Acrogeria Prominent vasculature Spondylodysplastic EDS (spEDS) If a person meets the diagnostic criteria for spEDS, genetic testing should be done to confirm the diagnosis

Often the claims have stretched and distorted the data: While its true that the package of antioxidants, minerals, fiber, and other substances found naturally in fruits, vegetables, and whole grains helps prevent a variety of chronic diseases, it is unlikely that high doses of antioxidant supplements can accomplish the same feat

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DMS contributes to the development of clouds and climate regulation [23]