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Oral administration of NAC was previously reported to improve photoreceptor function in rd10 mice [12] and in Phase 1 clinical trial [13], outlining a new promising minimally invasive route for RP treatment

Operating as a ligand for IGF1R, LR3 IGF-I binds to the alpha subunit, initiating the activation of intrinsic tyrosine kinase activity, autophosphorylating tyrosine residues in the beta subunit