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FDH Formate dehydrogenase is a mitochondrial-localized NAD-requiring enzyme while the HCOOH is getting into the mitochondrial, FDH will oxidize the formic acid into CO2, and reduce NAD+ to NADH with a high degree of specificity

Transcriptomic support is currently more limited and indirect, because the available single-cell RNA sequencing datasets in human severe AP are derived predominantly from peripheral blood immune cells and therefore reflect systemic inflammatory activation rather than pancreas-specific inter-organellar signaling within acinar cells (98)

however, the long reaction time (up to 12 h), low quantum yields (QYs) (about 6%) and complicated protocols are some of the existing limitations