however, in specific genetic contexts, its abnormal splicing or functional inactivation may lead to insufficient intracellular iron accumulation, thereby limiting Fenton reaction efficiency and attenuating radiotherapy-induced lipid peroxidative damage (196).Conversely, overexpression of ACSL3, a member of the long-chain fatty acid-CoA ligase family, enhances the activation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), promoting the synthesis of oxidation-sensitive phospholipids like AA-PE and significantly increasing membrane susceptibility to radiotherapy-induced lipid peroxidation (197)
This syndrome is characterized by accelerated aging, with affected individuals displaying features such as hair loss, joint abnormalities and cardiovascular disease, with a reduced lifespan
The hyperlipidemic cataract group had reduced GSH and higher malondialdehyde contents than the normal cataract group, reflecting reduction of antioxidative capacity and increase of damages caused by free radicals under a hyperlipidemic status (20)
10.3390/ijms26115060 76 KonstantinidouF.BudaniM
