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Oligomeric -synuclein binds to F0/F1-ATP synthase causing oxidation of its -subunit and also lipid peroxidation of the mitochondrial membrane, which in combination with calcium overload, leads to the formation and opening of additional mitochondrial permeability channels and, as a consequence, cell death (Ludtmann et al., 2018)

Although promising for disrupting tumor proliferation and immune evasion, STAT3 and JAK inhibitors face significant limitations due to poor BBB penetration

The roGFP-iL gene was purchased from Addgene (Watertown, MA, USA) in a pQE30 plasmid harboring an ampicillin resistance gene