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16 However, as individual responses to these drugs may vary inexplicably, it is reasonable to offer patients a trial of a different PDE5 inhibitor before proceeding to more invasive treatments

2.4 Antioxidants 2.4.1 N-Acetylcysteine (NAC) NAC is a synthetic acetylated derivate of the endogenous amino acid L-cysteine, a precursor of glutathione, a powerful free radical scavenger of reactive oxygen species (Ziment, 1988)