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The outer membrane protein TbpA and the surface lipoprotein TbpB work together to extract iron from human transferrin, with TbpA forming the channel for iron transport across the membrane and TbpB acting as an initial binding partner that enhances iron release and transferrin removal

LTF therefore appears to be a multifaceted molecule with many positive effects on metabolism, immunity and neurological function that would be of benefit in AD

The invention contemplates using the same or different reagents discussed herein to achieve preparation of the cations of the invention

PMID 25738459 ScienceDirect / Cell Metabolism Commentary on Lee et al