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For instance, the activation of JNK can lead to the phosphorylation of cAMP response element-binding protein (CREB), a critical transcription factor that promotes BDNF expression

Stress stimulates corticotrophin-releasing hormone (CRH), resulting in mast cell degranulation and the release of pro-inflammatory cytokines (Evers et al

Each of the current treatment approaches have their positive and negative attributes in terms of the impact that they have on the microenvironment, but on top of this, there are considerations including the location and accessibility of the TME which all play a role in how the damaged microenvironment can be reversed

Dibbern DA, Montanaro A