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Comment: Multiple commenters requested that CMS adjust the ASC payment for CPT code 64590 (insertion or replacement of peripheral neurostimulator pulse generator) from the proposed $16,502.60 to $18,330.98 to maintain consistency with historical methodology where ASC payments typically represent 110 percent-113 percent of the device offset, rather than the proposed 102 percent

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Disulphide bond integrity: Uniquely important for this compound, the disulphide bond between Cys-7 and Cys-15 must be correctly formed