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Keywords: vitamin B-12, cobalamin, proton-pump inhibitor, H 2 -receptor antagonist, metformin, holotranscobalamin, homocysteine, methylmalonic acid, multiple analyte testing Introduction There is general consensus that gastric acidlowering drugs, including proton pump inhibitors (PPIs) and H 2 -receptor antagonists (H2RAs), and the antidiabetes drug metformin can reduce circulating vitamin B-12 concentrations with prolonged use

Full blood count, liver function test, urea and electrolytes, blood glucose, thyroid function and antibody profiles, including thyroid antibodies, and thyroid ultrasound were performed

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This substantiates the evidence that the spared white matter holds the key to the functional motor recovery of the hind limbs after SCI and is closely correlated with the functional restoration of the paralyzed hind limbs [50,51,52]