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In AT, obesity induces pronounced ER stress that fundamentally disrupts metabolic homeostasis through multiple tissue-specific mechanisms (80, 98)

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doi: 10.1016/j.biopha.2019.109688 250 ZouYPalteMJDeikAALiHEatonJKWangWet al

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doi: 10.3390/cells8020198

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doi: 10.1016/j.jbiotec.2010.01.012 28 CostaECMoreiraAFde Melo-DiogoDGasparVMCarvalhoMPCorreiaIJ

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