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The low-energy conformation of the Epitalon peptide was determined, revealing a total charge of 2 at physiological pH 7.0 and an energy value of 294.43 kcal/mol

Previous studies have shown that the absence of C-tail phosphorylation increases the flexibility of the linker between the SH3 and SH2 domains, known as an inducible snap lock, that may further enable the SH3 domain to accommodate not only extended polyproline sequences but also structurally diverse interaction partners 23

Parker JS, Parrish CR

The effect of apamin, a small conductance calcium activated potassium (SK) channel blocker, on a mouse model of neurofibromatosis 1