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In granulosa cells, miR-484 specifically targets YAP1 mRNA, resulting in mitochondrial dysfunction marked by decreased ATP synthesis, increased mitochondrial membrane potential (MMP) depolarization, and decreased reactive oxygen species (ROS) clearance

SCFAs are known to signal through Gproteincoupled receptors (such as GPR41 and GPR43) and histone deacetylase inhibition, pathways that play important roles in maintaining mucosal homeostasis [212, 219]

Undoubtedly, glycemic control remains the cornerstone for preventing and delaying the progression of DGE, while the search for targets to repair and regulate the ENS continues to be a major focus of current research

Mann-Whitney U test, p 0.05