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In most cases, issues related to perceived stress, glycemic control, circadian rhythm, cortisol feedback control (in the hypothalamus and/or pituitary), inflammatory signaling, or tissue-specific glucocorticoid effects will have much more to do with a treatment protocol than direct support of adrenal function

A supplement may be recommended if you have any concerns regarding your B vitamin status or any specific dietary requirements

Neuroprotection Emerging Evidence Evidence Rating: Emerging (Interesting animal data, limited scope) Neurological applications show promise but require more research: Dopaminergic system protection Peripheral nerve regeneration Traumatic brain injury Alcohol-related neurological damage The GABAergic system interactions and NO modulation provide mechanistic support, but this area needs more study

PMID: 24746582