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However, many alkylating agents, oxidative stress and excess substrates for conjugation can lead to the depletion of glutathione thus rendering cells more susceptible to the toxic effects of chemicals [64]

Cancer, 11 , 726734

Several studies of HCC cells have shown that inhibition of NFE2L2 expression can increase the anticancer activity of the chemicals erastin and sorafenib, with inhibition of NFE2L2 inducing ferroptosis and killing HCC cells (64)

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