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MSG increased the oxidative stress that leads to kidney tissue and function damage via several mechanisms including: (1) reduced activities of some antioxidant enzymes as catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) and glutathione (GSH) and increased MDA level in the kidney, (2) increased activity of -ketoglutarate dehydrogenase, a potential ROS generator, (3) enhanced free radical generation through increased intracellular calcium level, and (4) decreased GSH levels that may increase ROS-induced renal cell damage [12, 14, 60]

I polled many of my soft tissue pathology colleagues in the United States and in other countries, and it is clear there is a lack of uniformity in the approach to utilizing these techniques in the distinction of dedifferentiated liposarcoma from other types of pleomorphic sarcoma

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Injectable use lacks the same regulatory approval but draws on the same safety mechanisms