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Our mCherry model is well suited to address this question, as we previously showed that adult neurons in this background can selectively eject material in large (~3.8 m) membrane-bound vesicles called exophers that can include protein aggregates 6

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Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N (2001) Ghrelin in domestic animals: distribution in stomach and its possible role

Consequently, Nb1053 has been radiolabeled with 18 F, resulting in a radioconjugate excreted via the hepatobiliary system, that prevents renal accumulation without compromising tumor uptake [99,100,101,102,103,104,105,106,107,108,109]