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This multistep, one-pot process proceeds via the intermediacy of the isothiouronium salt, which is hydrolyzed in a separate step: [24] [25] CH 3 CH 2 Br + SC(NH 2 ) 2 [CH 3 CH 2 SC(NH 2 ) 2 ]Br [CH 3 CH 2 SC(NH 2 ) 2 ]Br + NaOH CH 3 CH 2 SH + OC(NH 2 ) 2 + NaBr The thiourea route works well with primary halides, especially activated ones

4423-A IDENTIFICATION OF microRNAs INVOLVED IN RESISTANCE OF LENVATINIB UNDER HYPOXIA IN HEPATOCELLULAR CARCINOMA Mari Satoh 1,2 , Takayuki Kogure 2 , Takehito Ito 3 , Masanori Takahashi 2 , Kensuke Usui 2 , Kouji Okada 2 and Kennichi Satoh 2 , (1)Tome City Toyosato Hospital, (2)Tohoku Medical and Pharmaceutical University, (3)Tohoku Medical and Pharmaceutical University Wakabayashi Hospital Background: Among the multi-kinase inhibitors for the treatment of hepatocellular carcinoma (HCC), lenvatinib has shown a superior response rate

The higher peptide content means fewer vials consumed during maintenance phases