glutathione s transferase sigma aldrich Sigma-Class Transferases (GSTσ): A New Target with Potential for Helminth Control Upon conjugation of the thiol group of glutathione to the CDNB substrate GST K1-1, Recombinant Human

Shi Y, Tsao T, Lu H, Konoplev S, Schober WD, Andreeff M , Konopleva M

Dosages may range from 100-1,000mcg daily

J.BenfeitoS.SilvaV.ChavarriaD.BorgesF.et al

ARA-290 received FDA Orphan Drug Designation for this indication TRPV1-mediated pain models ARA-290 demonstrated specific inhibition of TRPV1 channel activity, relieving capsaicin-induced mechanical hypersensitivity in pre-clinical nociceptor models Complex Regional Pain Syndrome (CRPS) investigational studies have examined ARA-290 in CRPS models due to its dual anti-inflammatory and nociceptor-targeting mechanism Chronic neuropathic pain multiple studies confirm ARA-290 reduces neuroinflammation in the spinal cord by suppressing TNF-, IL-1, and other pro-inflammatory cytokines that maintain chronic pain states Neuroprotection and CNS Research: Cerebral ischaemia/stroke models Wang et al