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The salvage pathway utilizes the precursors NAM, NMN, and NR

Metabolism 170 , 156330

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Our model is further supported by three independent mutants, resulting in very similar effects on viral negative strand synthesis: D1467G in NS3h affecting the interaction with NS5B, an intergenotypic X-tail chimera (3X) disturbing sequence-specific interactions with NS5B and a mutation of the penultimate nucleotide of the HCV genome (G2U), likely affecting primer synthesis by NS5B