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Sharma et al., 2022) Contrary to NOX1 and NOX2, NOX4 only requires p22phox (the ubiquitous protein encoded by the CYBA gene located on the long arm of chromosome 16 at position 24) and releases hydrogen peroxide instead of superoxide (Moghadam et al., 2021) Three NOX isotypes are expressed in the vascular smooth muscle cells (VSMC) that line the blood vessels of mice

Eicosanoids derived from omega 6 fatty acids tend to be pro-inflammatory while those derived from omega 3 fatty acids tend to be anti-inflammatory or perhaps more accurately, less active

Effective pharmacological treatments are urgently needed

236,237 The EBV lytic proteins and tumorigenic functions are listed in Table 6