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In all differential expression tests, a gene was considered significant if the fold change was more than 2 and q value was less than 0.05

BPC-157 (Body Protection Compound-157) is a 15-amino acid gastric pentadecapeptide known for its remarkable tissue healing and protective properties, while TB-500 (Thymosin Beta-4) is a 43-amino acid peptide that plays fundamental roles in cell migration, tissue remodeling, and wound repair

miR-16 and miR-223 are also identified as targets to distinguish patients with early RA from healthy individuals ( Most of the aberrant miRNA levels can alter the secretion of inflammatory cytokines or MMPs, further affecting the procession of RA

In addition, the finding of a mutation in the VHL somatic gene adds strength to these observations, although it would be useful if this finding were replicated in other settings