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ENS structure and neurochemistry resemble that of the CNS, therefore pathogenic mechanisms that give rise to CNS disorders might also lead to ENS dysfunction, and nerves that interconnect the ENS and CNS can be conduits for disease spread

Vitamin B12 deficiency in DNA synthesis reduction is explained by the folate trapping theory as methyl-tetrahydrofolate.(...) methionine synthase cannot be activated and folate remains as methyl-FH4, which also causes a functional folate deficiency, thus explaining megaloblastic anemia." SOURCE: Interrelation of Vitamin B12 and Folic Acid

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