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Therapeutic Research Protocol Dose: 0.5 0.9 mg (= 1018 clicks) Duration: 3 4 weeks Frequency: 2 daily, divided doses Cycle Interval: 4 weeks off before repeating Goal / Description: Higher-dose protocol used in stress-response and GABAergic modulation studies

In addition, the authors would like to express their sincere gratitude to the Medical Experimental Center of the School of Basic Medicine and Public Health, Jinan University, for providing some of the experimental equipment for this study