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Description

A.Frontela-SasetaC

Chronic retention of toxic bile acids can cause oxidative stress, apoptosis and fibrosis leading to cirrhosis

PMID: 37364590

Specifically, hypermethylation of CpG sites at gene promoters affects specific tumor suppressor genes such as SLIT2, PTEN, OPCML, RASSF1A, p16, MLH1, E-calmodulin and APC (58)