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confirmed that ferroptosis was involved in the development of RM-associated AKI, and curcumin could alleviate RM-induced kidney injury via inhibiting ferroptosis of renal tubular epithelial cells ( FTH /- mice displayed a higher mortality and more serious kidney injury in RM-induced AKI model compared with wild-type mice, indicating that FTH exerted a protective effect on renal tubular injury in AKI (Zarjou et al., 2013)

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Based on the structural map of SARS-CoV-2, about 6% of the viral proteome mimics human proteins, while nearly 7% has been implicated in cellular hijacking mechanisms, and about 29% of proteome self-assembles into heteromeric components to support viral replication 31