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When AKR1C1 was knocked down, cell viability was reduced, and lipid peroxidation was increased

They found that the expression level of lncRNA has shown a strong correlation with OS, indicating that they might modulate redox status in diabetic complications, and the emerging scientific evidence depicts that MTAs can mitigate mitochondrial OS caused by hyperglycemia in DM, providing promising OS-targeting therapeutic strategies

Such a trial to study treatment of hyperpigmentation with glutathione must also study long-term effects of single treatment, maintenance of effect over time and value of at least one repeat treatment