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Category 1 (Green Light) consists of nominated substances that may be used pending final FDA evaluation

Moreover, the zebrafish in vivo assay reveals that T1 effectively reduces melanogenesis with no adverse side effects

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CAT activity also increased (1.41.5-fold), whereas GR activity declined (2.5-fold), reflecting a pattern of early enzymatic activation followed by exhaustion with disease progression (Pavlova et al., 2025)