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Historically, transcription factors like C/EBP have posed therapeutic challenges due to their absence of enzymatic activity and well-defined small-molecule binding sites, rendering them difficult to target directly with traditional drugs (Hattori et al., 2003)

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As we gain experience with the application of the methodology for recalculating expenditures to account for the impact of improper payments on Shared Savings Program financial calculations being finalized with this final rule, we may address these factors and related considerations further in future notice and comment rulemaking

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