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To investigate how conditions in the aged spleen impact T cell functions, naive CD4 + T cells (CD4 + CD25 CD62L + CD44 lo ) were purified from the spleens and LNs of aged mice and activated ex vivo using plate-bound anti-CD3 and anti-CD28

Oxidative phosphorylation is disrupted at complex I and II in GSH-deficient follicular B cells To determine whether the accumulation of succinate in Gclc -deficient FoB was caused by a dysfunctional ETC, we assessed the respiratory parameters of each ETC complex