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RNA sequencing of LPS/IFN--stimulated M1 macrophages after cre Fsp1 f/f Fsp1 knockdown confirmed pronounced glycolytic remodeling and reduced expression of key energy metabolism enzymes (Fig

The arrangement and dimerisation of the B 12 binding domains, which consist of a Rossmann fold and associated four-helix bundle, is similar to the corresponding CarH dimer core module (RMSD = 1.37 for 237 C-alphas), with the dark state Sas Pcob and Ab Pcob forming head-to-tail dimers 4 (Fig