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(Rath et al., 2017) examined the TMA-forming potential of microbial communities and found that cutC amplicons were related to various taxa, but that the sequences showed low nucleotide identities to reference sequences, whereas cntA amplicons showed high identities to reference sequences, principally sequences from Escherichia coli

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This primarily affects low-expression regions with high CpG density (HCP), while high-expression CGI promoters resist methylation, though the reasons for this are unclear (172)