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GPx-4 plays a crucial role in cellular defense against oxidative stress, primarily by reducing lipid hydroperoxides to their corresponding alcohols and converting free hydrogen peroxide into water, thereby preventing lipid peroxidation of cell membranes

In a clinical trial that integrated single-cell RNA-sequencing with single-cell proteomics of blood and peripheral blood mononuclear cells (PBMCs), immature neutrophil precursors, and dysfunctional mature neutrophils expressing programmed death-ligand 1 appeared in severe COVID-19 cases

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This condition results in anemia because the life span of the affected red blood cells is reduced by about 90%