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Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)

A total of 1,456 HE were documented within the dataset, of which 1,355 (93.06%) were associated with ADEs, affecting 1,264 patients

However, co-treatment of cells with the ferroptosis inhibitor Ferrostatin-1 and NAC can reverse ferroptosis (186)

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