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TB-500 and Neurological Recovery Research In a rat embolic stroke model, administration of T4 at 24 hours after middle cerebral artery occlusion and every 3 days for 4 additional doses produced significant improvement in functional neurological outcome with evidence of axonal remodelling at the ischaemic boundary, increased oligodendrocyte precursor cells in the SVZ, striatum, and corpus callosum, and increased mature oligodendrocytes suggesting a mechanism involving axonal remodelling rather than direct neuroprotection

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Glutathione proved significant ROS reduction following the mitomycin C test, carried out according to the following protocol: after ROS induction in skin cells through the use of the genotoxic agent mitomycin C, keratinocytes cells are treated with glutathione and placebo to evaluate the intracellular ROS reduction