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Description

(1980) Table 12 (contd)

10 Canonical NF-B pathway Components of canonical NF-B pathway NF-B family The precursor molecule p105 undergoes ubiquitination upon induction by the ubiquitin ligase Kip1 ubiquitination-promoting complex subunit 1 (KPC1), followed by proteasomal disassembly into the active form p50, and the nuclear localization sequence (NLS) masked by the remote structural domain of the p110 precursor is exposed, allowing cytoplasmic/nuclear signaling to proceed