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It was not a clinical trial and did not establish a human treatment protocol

The answer is a resounding yes

Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

And heres the part that should worry you more than the legal gray zone: when most people say I bought 5-Amino-1MQ, what they mean is they added a bottle to a cart on a research-chemical site, clicked past a checkbox claiming its for research only, and received capsules or powder with no clinician anywhere in the chain